NFT is an innovative patented muco-adhesive filmstrips technology, for administration of active ingredients via oral mucosal membranes.
EXECUTIVE SUMMERY
Maabarot group developed an innovative patented muco-adhesive filmstrips technology, for administration of active ingredients via oral mucosal membranes.
Disintegration time of the filmstrips dissolution is modulated to provide
improved bioavailability to each ingredient.
New application enables enhanced oral absorption of slow or limited absorption ingredient in the gastro-intestinal tract.
Technology protected by 2 patents.
First Products launch:
- NFT-Saffron (Mood conditions)
- NFT-Coenzyme Q10
ORAL FILMS ADVANTAGES
Innovative dosage form technology for food supplements
Convenient & Easy to Administer
Each film is packed separately in Alu-Alu sachet and administered under the tongue or buccal. Starts to dissolve immediately in the mouth without water
Fast Acting
The active substance starts release immediately in the mouth (in fast acting oral films).
Improved Absorption
The active substance enters the bloodstream directly via the oral mucosa, without having to first pass through the gastrointestinal tract
ORAL FILM TECHNOLOGY
Blue ocean, fast-growing market
- $2 Billion market
- Very high growth rates and growing popularity among consumers
- Variety of products available on the market, mostly pharmaceuticals
RX
Addicted to opioid drugs
Erectile dysfunction “Viagra”
OTC & FOOD SUPPLEMENTS
Gas relief Novartis
Melatonin 3 mg fast dissolving strips
Vitamin D 1,000 mcg fast dissolving strips
Vitamin b12 1,000 mcg fast dissolving strips
Oral nicotine
Snoring relief
Cold & cough Novartis
Listerine PocketPaks Breath Strips
OUR UNIQUE VALUE
NFT PROPRIETARY TECHNOLOGY
Tailored slow-dissolving and long residence time, muco adhesive- sublingual and buccal.
Enhanced absorption and improves bioavailability. Fast onset and direct absorption to the bloodstream.
Clean label product, based on special types of alginates, extracted from brown seaweeds. natural polymer (GRAS).
Lipophilic and water-soluble active ingredients.
The technology covered by 2 Patents.
IP PROTECTED
Patent 1
US Patent 8,840,935, issued on Sept. 23, 2014. Orally administrable films and preparation – Selected alginates as major film former.
Patent 2
On 4.11.2020, PCT was submitted to a European examiner, answer within 6 months.
“Orally administrable films comprising POORLY WATER SOLUBLE BIOACTIVE MATERIALS and methods for preparation thereof (including CoQ10).”
NFT Film Vs. ORAL DOSAGE
TABLETS
GEL CAPS
NFT
SAFFRON
MOOD HEALTH
Mood and mental health supplements market is skyrocketing in recent years.
- Fastest growing dietary supplement category in 2019 and 2020 (COVID-19 – a major driving force).
- Global mood and mental health supplement market expected to triple in five years.
- The spike in demand for mood and mental health supplements undoubtedly includes new customers.
- Saffron is well known in its therapeutic attributes to improve the mood and lower stress level.
Mood and mental health sales in the USA (M,$)
SAFFRON
Nature’s remedy for Mood Health, Depression and Stress
“Saffron supplementation can improve symptoms of depression in adults with major depressive disorder (MMD)”
“Saffron supplementation and the antidepressant groups were similarly effective in reducing depression symptoms”
Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials.
Meta-analysis
“Saffron can improve the symptoms and effects of depression, premenstrual syndrome, sexual dysfunction and infertility.”
A Systematic Review of Randomized Controlled Trials Examining the Effectiveness of Saffron (Crocus sativus L.) on Psychological and Behavioral Outcomes.
Systematic Review
“Saffron is effective in reducing anxiety and improving the quality of sleep among diabetic patients.”
Effect of saffron oral capsule on anxiety and quality of sleep of diabetic patients in a tertiary healthcare facility in southeastern Iran: A quasi-experimental study.
“Saffron increased mood, reduced anxiety and managed stress without side effects, offering a natural alternative to standard treatments.”
affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial
“Saffron was effective in the treatment of MDD and had comparable efficacy to synthetic antidepressants.”
“Saffron was also a safe drug without serious adverse events reported.”
Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials
Meta-analysis
“In summary, our results clearly suggest that saffron reduces the severity of depression based on HAM‑D and BDI scores.”
“Saffron has a significant effect on the severity of depression and saffron is significantly more effective than placebo and non-inferior to tested antidepressant drugs.”
The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis
Meta-analysis
“Saffron is a safe alternative medication for improving depressive symptoms of postpartum depression.”
The saffron efficacy has been shown to be similar to FLUOXETINE or IMIPRAMINE, the two main active compounds of pharmaceutical drugs used to treat those disorders, without any side effects.
Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial- Pharmacopsychiatry 2017.